cc chemical consulting

 

Prof. Dr. Dorothea Ehlers                                                                                                          

Schönburgstr. 2

D-12103 Berlin

Tel.:+49-30-75008562 
Fax: +49-30-71093821

email:d.m.s.ehlers@cc-chemical-consulting.de

 

 

Ewald A.H., Ehlers D. and Maurer H.H.: Metabolism and toxicological detection of the designer drug 4-chloro-2,5-dimethoxyamphetamine in rat urine using gas chromatography-mass spectrometry. Anal Bioanal Chem (2008) 390:1837-1842

 

 

Abstract

Studies are described on the metabolism and the toxicological analysis of the amphetamine-derived designer drug 4-chloro-2,5-dimethoxyamphetamine (DOC) in rat urine using gas chromatographic-mass spectrometric techniques. The metabolites identified indicated that DOC was metabolized by O-demethylation at position 2 or 5 of the phenyl ring partly followed by glucuronidation and/or sulfation. The author’s systematic toxicological analysis procedure using full-scan gas chromatography-mass spectrometry after acid hydrolysis, liquid-liquid extraction and microwave-assisted acetylation allowed the detection of an intake of a dose of DOC in rat urine that corresponds to a common drug user’s dose. Assuming similar metabolism, the STA procedure described should be suitable as proof of an intake of DOC in human urine.

 

 

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